Cross linked orgotein

Details Cross linked orgotein Cross linked orgotein

C - Chemistry, Metallurgy

12

N

530/15.06, 167/1

C12N 9/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1059911

ABSTRACT OF THE DISCLOSURE A water-soluble, injectable cross-linked orgotein having a molecular weight of up to 500,000 is provided herein. The orgotein molecule is intermolecularly cross-linked by at least one organic bridging group with at least one molecule of a water-soluble, injectable non-antigenic protein. The organic bridging group is formed by the reaction of orgotein or a mixture of orgotein and another water-soluble, injectable non-antigenic protein, with an organic difunctional cross-linking agent. This novel cross-linked orgotein has a substantially longer half-life in the blood after injection than orgotein.

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