Cross-linked particles

Details Cross-linked particles Cross-linked particles

C - Chemistry, Metallurgy

08

L

C08L 1/28 (2006.01) A61K 9/51 (2006.01) A61K 9/52 (2006.01) C08B 15/00 (2006.01) C08B 15/10 (2006.01) C08G 69/10 (2006.01) C08J 3/24 (2006.01) C08L 5/04 (2006.01) C08L 77/04 (2006.01) C08L 89/06 (2006.01)

Patent

CA 2302523

Cross-linked particles are provided that are useful for delivery of pharmaceutical agents. The particles comprise at least one polymeric compound and a spacer compound, where the polymeric compound and the spacer each comprise reactive carboxyl, hydrazidyl, amino and/or thiol groups. The particles are cross-linked via covalent linkage of the reactive groups on the polymer and spacer respectively. Compositions comprising pharmaceutical agents contained within the particles are disclosed. Methods for preparing the particles, for encapsulating pharmaceutical agents within the particles, and for using the particles for controlled release of the pharmaceutical agent within the patient also are provided.

L'invention porte sur des particules réticulées qui sont utiles pour administrer des agents pharmaceutiques. Ces particules comprennent au moins un composé polymère et un composé espaceur, chacun étant constitué de groupes réactifs carboxyle, hydrazidyle, amino et/ou thiol. Les particules sont réticulées par une liaison covalente des groupes réactifs du polymère et de l'espaceur. L'invention porte également sur des compositions comprenant des agents pharmaceutiques contenus dans ces particules, sur des procédés de préparation des particules, d'encapsulation des agents pharmaceutiques dans les particules, et sur des procédés d'utilisation des particules permettant la libération contrôlée de l'agent pharmaceutique administré à un patient.

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