Cross-linked polymers for removing bile salts from a patient

C - Chemistry – Metallurgy – 08 – F

Patent

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Details

C08F 265/04 (2006.01) A61K 31/74 (2006.01) A61K 31/785 (2006.01) A61K 31/787 (2006.01) A61K 31/795 (2006.01) C08F 8/00 (2006.01) C08F 8/02 (2006.01) C08F 220/34 (2006.01) C08F 220/60 (2006.01) C08F 265/10 (2006.01)

Patent

CA 2192592

A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly cross-linked polymers characterized by a repeat unit having formula (1) or copolymer thereof, where n is an integer, R1 is H or a C1-C8 alkyl group; M is (a) or -Z-R2; Z is O, NR3, S, or (CH2)m; m = 0-10; R3 is H or a C1-C8 alkyl group; and R2 is (b) or (c) where p = 0-10, and each R4, R5, and R6, independently, is H, a C1-C8 alkyl group, or an aryl group, the polymers being non-toxic and stable once ingested.

L'invention se rapporte à un procédé d'élimination des sels biliaires d'un patient par échange d'ions, procédé qui consiste à administrer au patient une quantité thérapeutiquement efficace d'un ou plusieurs polymères fortement réticulés, qui se caractérisent par une unité de répétition ayant la formule (1) ou un copolymère de ceux-ci, formule dans laquelle n est un nombre entier; R<1> représente H ou un groupe alkyle C1-C8; M représente la formule (a) ou Z-R<2>; Z représente O, NR<3>, S, ou (CH2)m; m = 0-10; R<3> représente H ou un groupe alkyle C1-C8; R<2> représente la formule (b) ou (c) où p = 0-10, chaque R<4>, R<5> et R<6> représente indépendamment H, un groupe alkyle C1-C8 ou un groupe aryle, les polymères étant non toxiques et stables une fois ingérés.

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