Cross-linked polysaccharide drug carrier

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/36 (2006.01) A61K 9/14 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C08B 37/00 (2006.01) A61K 31/715 (2006.01)

Patent

CA 2294756

A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.

La présente invention concerne un vecteur et une méthode permettant de le préparer afin qu'il soit utilisé dans l'administration d'agents thérapeutiques. Un polysaccharide est mis à réagir avec un agent d'oxydation de manière à ouvrir les noyaux de glucides du polysaccharide et former des groupes aldéhydes. Les groupes aldéhydes sont mis à réagir pour former des liaisons d'oxime covalentes avec un second polysaccharide, chacun des premier et second saccharides étant sélectionné dans le groupe constitué par un acide hyaluronique, un dextrane, un sulfate de dextrane, un sulfate de chondroïtine, un sulfate de dermatan, un sulfate de kératane, un héparane, un sulfate d'héparane et un alginate.

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