Cross-linked vinyl polymers with bile acid adsorbing effect

Details Cross-linked vinyl polymers with bile acid adsorbing effect Cross-linked vinyl polymers with bile acid adsorbing effect

C - Chemistry, Metallurgy

08

F

C08F 8/44 (2006.01) A61K 31/785 (2006.01) A61K 47/48 (2006.01) C07C 233/38 (2006.01) C08F 20/36 (2006.01) C08F 20/66 (2006.01) C08F 22/10 (2006.01) C08F 22/38 (2006.01) C08F 271/00 (2006.01)

Patent

CA 2281602

Compounds have the general formula (II), in which A stands for hydrogen or C1- 9-alkyl; G and E independently represent O or NH; d and a independently represent an integer from 2 to 10; R1 and R2 independently represent C1-9- alkyl; T stands for C2-200-alkylene, optionally interrupted by phenylene, one of the groups (a), (b), (c), (d) or (e), 1 to 10 non-adjacent oxygen atoms or groups -N+R3R4-, in which R3 and R4 independently represent C1-9-alkyl, and X- stands for an acid anion. Also disclosed are polymers produced from these compounds and their use as lipid lowering agents.

L'invention concerne des composés de formule générale (II), dans laquelle A désigne hydrogène ou alkyle C¿1-9?, G et E représentent indépendamment O ou NH; d et a représentent indépendamment un nombre entier de 2 à 10; R?1¿ et R?2¿ représentent indépendamment alkyle C¿1-9?; T désigne alkylène C¿2-200?, le cas échéant interrompu par phénylène, un des groupes (a), (b), (c), (d), ou (e), 1 à 10 atomes d'oxygène non adjacents ou des groupes -N?+¿R?3¿R?4¿-, dans lesquels R?3¿ et R?4¿ représentent indépendamment alkyle C¿1-9?, et X?-¿ désigne un anion acide. L'invention concerne également des polymères produits avec ces composés et leur utilisation comme agents hypolipidémiants.

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