C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 6/097 (2006.01) A61K 31/00 (2006.01) A61K 47/36 (2006.01) A61L 27/52 (2006.01) A61L 31/04 (2006.01)
Patent
CA 2521961
The invention relates to a method for cross-linking at least one polymer, selected from the polysaccharides and the derivatives thereof, application thereof in an aqueous solvent, by the action of an effective and non-excessive quantity of at least one cross-linking agent, characterised in being applied to a mixture including at least one polymer of low molecular weight and at least one polymer of high molecular weight, a method for preparation of an injectable monophase hydrogel with at least one cross-linked polymer selected from polysaccharides and the derivatives thereof and the cross-linked polymers and injectable monophase hydrogels which may be obtained respectively by the methods above.
La présente invention a pour objet : - un procédé de réticulation d~au moins un polymère, choisi parmi les polysaccharides et leurs dérivés, mis en oeuvre en solvant aqueux par action d~un quantité efficace et non excessive d~au moins un agent de réticulation, caratérisé en ce qu~il est mis en oeuvre sur un mélange renfermant au moins un polymère de faible masse moléculaire et au moins un polymère de forte masse moléculaire ; - un procédé de préparation d~un hydrogel monophasique injectable d~au moins un polymère réticulé choisi parmi les polysaccharides et leurs dérivés ; - les polymères réticulées et hydrogels monophasiques injectables, susceptibles d~être respectivement obtenus par chacun desdits procédés.
Lebreton Pierre
Allergan Industrie Sas
Corneal Industrie
Sim & Mcburney
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