Cross-protective human monoclonal antibody compositions

Details Cross-protective human monoclonal antibody compositions Cross-protective human monoclonal antibody compositions

C - Chemistry, Metallurgy

07

K

167/139, 167/37,

C07K 16/08 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339013

Cell lines have been produced that secrete human monoclonal antibodies capable of binding to molecules of different bacterial species. These antibodies have been found to be protective against lethal challenges of various bacterial genera. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included. Prior to filing of this patent application the continuous transformed human cell lines 9B10, 4F10, 4B9, 7D7, and 9C3, described herein, were deposited in the American Type Culture Collection and given the designations CRL 9006, CRL 9007, CRL 9008, CRL 9009, and CRL 9239, respectively.

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