Cross-protective salmonella vaccines

Details Cross-protective salmonella vaccines Cross-protective salmonella vaccines

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 39/112 (2006.01)

Patent

CA 2072633

2072633 9106317 PCTABS00005 Vaccines are provided for treatment of individuals for infections by gram negative bacteria. The vaccines are comprised of live avirulent Salmonella which are able to induce immunity to homologous and to heterologous Salmonella serotypes, and to other gram-negative enteric bacteria. The Salmonella of which the vaccine is comprised possess at least one mutation in a gene which globally regulates other genes, and which also possess a mutation in at least one other of the following type: a mutation either in a gene encoding an enzyme in a lipopolysaccharide synthesis, which results in a reversibly rough phenotype; or in a gene which regulates the synthesis of iron-regulated OMPs, such that the mutation leads to constitutive expression of these proteins. Strains useful for the production of these vaccines are also provided.

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