Cross-reacting monoclonal antibodies specific for e-selectin...

Details Cross-reacting monoclonal antibodies specific for e-selectin... Cross-reacting monoclonal antibodies specific for e-selectin...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191870

The invention provides monoclonal antibodies that specifically bind to P- selectin and to E-selectin. Humanized monoclonal antibodies also are disclosed. Many of the antibodies block the functional interactions of P- selectin and E-selectin with their respective counterreceptors.

L'invention concerne des anticorps monoclonaux qui se lient spécifiquement à la sélectine P et à la sélectine E. Elle concerne également des anticorps monoclonaux humanisés. Plusieurs de ces anticorps bloquent les interactions fonctionnelles de la sélectine P et de la sélectine E avec leurs contre-récepteurs respectifs.

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