C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A61K 35/74 (2006.01) A61K 39/085 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) C07K 14/31 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2450939
Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.
L'invention concerne des anticorps polyclonaux et monoclonaux qui présentent des réactions croisées aussi bien à l'égard de bactéries de staphylocoques à coagulase positive, p. ex. S. aureus, que de bactéries à coagulase négative, p. ex. S. epidermidis et S. hemolyticus, et sont capables de reconnaître des protéines de surface de bactéries de staphylocoques à coagulase positive et à coagulase négative. Ces anticorps peuvent être produits à partir de protéines de surface qui ont été isolées sur la base de caractéristiques pouvant être communes à S. aureus et à des staphylocoques à coagulase négative, et les protéines de surface recombinées servent à produire les anticorps de l'invention. L'invention concerne aussi des vaccins et des procédés utilisant ces protéines et anticorps pour traiter ou prévenir une large gamme d'infections staphylococciques.
Foster Timothy J.
Hutchins Jeff T.
Pallen Mark
Patti Joseph M.
Roche Fiona
Inhibitex Inc.
Shapiro Cohen
The Provost Fellows And Scholars Of The College Of The Holy And
Universita' Degli Studi Di Pavia
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