C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/725 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2683370
The present invention relates to a polypeptide comprising a human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. In a further aspect the invention provides a method for the identification of polypeptides comprising a cross-species specific binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3.epsilon. (CD3 epsilon).
La présente invention concerne un polypeptide comprenant un domaine de liaison humain capable de se fixer à un épitope de la chaîne (epsilon) du CD3 humain ou d'un primate autre que le chimpanzé, ainsi qu'un procédé destiné à la production de ce polypeptide. L'invention concerne également des acides nucléiques codant pour le polypeptide, des vecteurs comprenant ces acides nucléiques et des cellules hôtes comprenant le vecteur. Dans un autre aspect, l'invention concerne une composition pharmaceutique comprenant ledit polypeptide et des applications médicales du polypeptide. Un autre aspect de l'invention concerne une méthode d'identification de polypeptides comprenant un domaine de liaison spécifique d'espèces croisées capable de se fixer à un épitope de la chaîne (epsilon) du CD3 humain ou d'un primate autre que le chimpanzé.
Hoffmann Patrick
Kischel Roman
Klinger Matthias
Kufer Peter
Lutterbuese Ralf
Borden Ladner Gervais Llp
Micromet Ag
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