Cross-species-specific bispecific binders

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) C07K 14/725 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2682626

The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.

La présente invention concerne un polypeptide comprenant un premier domaine de liaison humain capable de se fixer à un épitope de la chaîne (epsilon) du CD3 humain ou d'un primate autre que le chimpanzé, un second domaine de liaison capable de se fixer au récepteur EGF, au récepteur Her2/neu ou à l'IgE d'un humain et/ou d'un primate autre que le chimpanzé, ainsi qu'un procédé destiné à la production de ce polypeptide. L'invention concerne également des acides nucléiques codant pour le polypeptide, des vecteurs comprenant ces acides nucléiques et des cellules hôtes comprenant le vecteur. Dans un autre aspect, l'invention concerne une composition pharmaceutique comprenant ledit polypeptide et des applications médicales du polypeptide.

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