C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 20/60 (2006.01) A61K 31/785 (2006.01) C08F 2/18 (2006.01) C08F 8/00 (2006.01) C08F 20/34 (2006.01) C08F 26/02 (2006.01) C08F 220/34 (2006.01)
Patent
CA 2139909
New bile acid sequestrant polymer compositions and a process for preparing the polymers in particulate form, preferably in spherical form, are described. The polymer particles are prepared by crosslinking an amine-containing polymer with an amount of a polyfunctional amine-reactive compound sufficient to crosslink the polymer so that it is essentially water insoluble and has bile acid sequestering efficacy greater than that of cholestyramine, preferably greater than about three times the efficacy of cholestyramine. A preferred polymerization process involves suspension polymer- ization of water-soluble amine-containing monomers, such as dialkylaminoalkyl (meth)acrylate esters and dialkylaminoalkyl (meth)acrylamides, in the presence of polyfunctional amine-reactive compounds, such as substituted dihaloalkanes. Pharmaceutical compositions containing the bile acid sequestrant polymer partides and a method for lowering blood cholesterol levels using the pharmaceutical compositions are also discribed.
Bliem Paul E.
Steffier Larry W.
Gowling Lafleur Henderson Llp
Rohm And Haas Company
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