C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 220/00 (2006.01) A61K 31/78 (2006.01) A61P 1/00 (2006.01) C08F 212/36 (2006.01) C08F 236/20 (2006.01) C08J 3/24 (2006.01)
Patent
CA 2735058
The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
La présente invention concerne des polymères réticulés échangeurs cationiques comprenant un groupe fluoro et un groupe acide, des compositions pharmaceutiques de ces polymères, des compositions d'un polyol linéaire et d'un sel d'un tel polymère. L'invention concerne également des polymères réticulés échangeurs cationiques dotés de propriétés physiques avantageuses, par exemple des combinaisons avantageuses de granulométrie, forme de particule, distribution granulométrique, viscosité, limite apparente d'élasticité, compressibilité, morphologie de surface, et/ou taux de gonflement. Ces polymères et ces compositions sont utiles pour lier le potassium dans le tractus gastro-intestinal.
Albrecht Detlef
Burdick Michael
Chang Han-Ting
Charmot Dominique
Chidambaram Ramakrishnan
Relypsa Inc.
Ridout & Maybee Llp
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