Crosslinked hyaluronic acid and its process of preparation

Details Crosslinked hyaluronic acid and its process of preparation Crosslinked hyaluronic acid and its process of preparation

C - Chemistry, Metallurgy

08

B

C08B 37/08 (2006.01) A61L 27/20 (2006.01)

Patent

CA 2668650

The invention relates to a cross-linked hyaluronic acid that can be produced by a method comprising: (a) activating a hyaluronic acid; (b) reacting the activated hyaluronic acid with a cross-linking agent containing an oligo- or polypeptide in a reaction medium at a pH of between 8 and 12 in order to obtain a cross-linked hyaluronic acid; (c) adjusting the pH of the reaction medium to a value between 5 and 7; and (d) precipitating the cross-linked hyaluronic acid in an organic solvent. The invention also relates to the above method, to a hydrogel obtained from said cross-linked hyaluronic acid, and to the use of the cross-linked hyaluronic acid for the production of implants that can essentially be used in plastic surgery.

La présente invention concerne un acide hyaluronique réticulé, susceptible d'être obtenu suivant un procédé comprenant : (a) l'activation d'un acide hyaluronique, (b) la réaction de l'acide hyaluronique activé avec un agent réticulant à base d'oligo- ou polypeptide, dans un milieu réactionnel ajusté à un pH de 8 à 12, pour obtenir un acide hyaluronique réticulé, (c) l'ajustement du pH du milieu réactionnel à une valeur allant de 5 à 7, et (d) la précipitation de l'acide hyaluronique réticulé dans un solvant organique. Elle se rapporte également au procédé ci-dessus, à un hydrogel obtenu à partir de l'acide hyaluronique réticulé et à l'utilisation de l'acide hyaluronique réticulé pour la fabrication d'implants utilisables notamment en chirurgie plastique.

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