Crosslinked polyalkyleneimine hydrogels with tunable...

Details Crosslinked polyalkyleneimine hydrogels with tunable... Crosslinked polyalkyleneimine hydrogels with tunable...

C - Chemistry, Metallurgy

08

G

C08G 65/48 (2006.01) C08G 65/00 (2006.01) C08G 65/32 (2006.01) C08G 73/00 (2006.01) C08G 73/04 (2006.01) C08J 3/075 (2006.01)

Patent

CA 2711455

One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties.

Cette invention concerne des procédés de fermeture dune plaie, dun tissu, ou de comblement dun espace vide, ou de fixation de mailles, de films ou dautres dispositifs à lintérieur de lorganisme. Dans certains modes de réalisation, la plaie est une plaie ophtalmique, pleurale ou durale, ou une maille de réparation de hernie. Linvention concerne la découverte remarquable selon laquelle lutilisation de certains agents de réticulation associés avec des polyalkylèneimines à des concentrations spécifiques peut aboutir à des hydrogels aux propriétés de dégradation ajustables.

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