Crosslinked polysaccharides, process for their preparation...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/00 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2132327

2132327 9319095 PCTABS00025 The invention concerns polysaccharides which are cross-linked with bi-functional cross-linking agents, no longer water-soluble although still bio-degradable, and swell by between 100 and 1000 %, the swelling, which is defined as the percentage weight increase, being determined by the equation: A = Gt - Go / Go x 100 wherein: A represents the percentage weight increase, Go the weight of the dry polymer, and Gt the weight of the swollen, water-saturated polymer. The invention also concerns a method for the production of the cross-linked polysaccharides and the use thereof for coating or embedding pharmacologically active substances or pharmaceuticals. The invention further concerns a medicament containing a substance either coated with or embedded in one of the cross-linked polysaccharides which acts in the colon or one which can be broken down while passing through the stomach or small intestine.

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