Crosslinking of bioprosthetic material to mitigate...

Details Crosslinking of bioprosthetic material to mitigate... Crosslinking of bioprosthetic material to mitigate...

A - Human Necessities

61

L

A61L 27/24 (2006.01) A61L 27/36 (2006.01) A61L 33/12 (2006.01)

Patent

CA 2344061

A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of: A) fixing the tissue; B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a cross-linking agent; C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto); and D) subjecting the bioprosthesis to terminal sterilization.

L'invention concerne une méthode de fixation de tissus biologiques, ainsi que des dispositifs bioprothétiques préparés selon cette méthode. La méthode consiste généralement: A) à fixer le tissu ; B) à traiter le tissu avec un mélange formé: i) d'un agent dénaturant; ii) d'un tensioactif; et iii) d'un agent de réticulation; C) à fabriquer ou à former la bioprothèse (par exemple en formant le tissu et en y fixant tout composant non biologique); et D) à soumettre la bioprothèse à une stérilisation finale.

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