Crush-resistant tablets intended to prevent accidental...

Details Crush-resistant tablets intended to prevent accidental... Crush-resistant tablets intended to prevent accidental...

A - Human Necessities

61

K

A61K 9/22 (2006.01)

Patent

CA 2643328

Water-insoluble matrix tablets which are capable of prolonged release of active principles liable to be diverted for drug addiction purposes, the said active principles being dispersed within a tabletting matrix composed of at least one excipient selected from the group consisting of pH-independent, water-insoluble delay polymers, inorganic excipients and mixtures thereof, and exhibiting a crush resistance of at least 4 MPa.

Comprimés matriciels insolubles dans l'eau capables de libérer de façon prolongée dans le temps des principes actifs susceptibles d'être détournés à des fins de toxicomanie, lesdits principes actifs étant dispersés au sein d'une matrice de compression constituée d'au moins un excipient choisi dans le groupe comprenant les polymères retard pH indépendants et insolubles dans l'eau, les excipients minéraux et leurs mélanges et présentant une résistance à l'écrasement d'au moins 4 MPa.

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