F - Mech Eng,Light,Heat,Weapons – 25 – D
Patent
F - Mech Eng,Light,Heat,Weapons
25
D
F25D 17/02 (2006.01) A01N 1/02 (2006.01) F25C 1/04 (2006.01) G01N 1/42 (2006.01)
Patent
CA 2446938
Disclosed is a biopharmaceutical material cryopreservation system(100) that includes a flexible sterile container(104) comprising a biocompatible polymeric material, and the flexible sterile container(104) containing biopharmaceuticals materials(110), and a freezing system(122) thermally coupled to the biopharmaceutical materials(110) via the flexible sterile container(104), and the freezing system(122) comprising a temperature sensor(116) that monitors a temperature of the biopharmaceutical materials(110) wherein the freezing system(122) comprises a feedback loop constructed to control a dendritic freezing front(128) velocity, within the biopharmaceutical materials(110), in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor(116).
L'invention concerne un système de cryoconservation (100) de matériau biopharmaceutique, qui comprend un contenant stérile flexible(104) comprenant un matériau polymérique biocompatible, ce contenant stérile flexible (104) contenant des matériaux biopharmaceutiques (110), ainsi qu'un système de congélation (122) relié thermiquement aux matériaux biopharmaceutiques (110) par l'intermédiaire du contenant stérile flexible (104). Le système de congélation (122) comprend un capteur thermique (116) qui contrôle une température des matériaux biopharmaceutiques (110), ainsi qu'une boucle de rétroaction conçue pour commander la vitesse d'un front de congélation dendritique (128), dans les matériaux biopharmaceutiques (110), dans une plage d'approximativement 5 millimètres par heure à approximativement 250 millimètres par heure en fonction d'une information de rétroaction reçue du capteur thermique (116).
Integrated Biosystems Inc.
Mccarthy Tetrault Llp
LandOfFree
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