Cryptic peptides and method for their identification

Details Cryptic peptides and method for their identification Cryptic peptides and method for their identification

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 39/35 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2247009

The invention provides a method of determining whether a peptide of a protein is a cryptic peptide, which method includes the steps of i) exposing T cells with the peptide in a primary challenge; ii) measuring the reactivity of T cells with the peptide in the primary challenge of step i); iii) exposing pre-challenged T cells with the peptide in a secondary challenge, wherein the pre-challenged T cells are obtainable by exposing the T cells to the protein; and measuring the reactivity of the pre-challenged T cells with the peptide in the secondary challenge of step iii), and the peptide is a cryptic peptide if T- cell reactivity is observable in the secondary challenge but not in the primary challenge.

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