C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/04 (2006.01) A61K 31/495 (2006.01) A61P 1/04 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2591757
A crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)- tetramethylcyclohexyl)phenyl]piperazine have excellent cellular adhesion inhibiting potency and cellular infiltration inhibiting potency. Therefore, these crystal and salt are useful as a preventive or therapeutic agent for various inflammatory diseases and autoimmune diseases caused by leukocyte adhesion and infiltration, such as inflammatory bowel disease (especially ulcerative colitis or Crohn~s disease), irritable bowel syndrome, rheumatic arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis.
La présente invention concerne un cristal et un sel de 1-cyclopropylméthyl-4-[2-(3,3,5,5)-tetraméthylcyclohexyl)phényl]pipérazine présentant une excellente activité en termes d~inhibition de l~adhésion cellulaire et d~inhibition de l ~infiltration cellulaire. Par conséquent, lesdits cristal et sel sont utiles en tant qu~agent préventif ou thérapeutique pour diverses maladies inflammatoires et auto-immunes induites par l~adhésion et l~infiltration leucocytaires telles que les maladies inflammatoires chroniques de l~intestin (en particulier la rectocolite hémorragique ou la maladie de Crohn), le syndrome du côlon irritable, la polyarthrite rhumatoïde, le psoriasis, la sclérose en plaques, l~asthme et la dermatite atopique.
Kotake Makoto
Osada Katsunobu
Yoneda Naoki
Eisai R&d Management Co. Ltd.
Marks & Clerk
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