Crystal for oral solid drug and oral solid drug for dysuria...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/08 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/404 (2006.01) A61K 45/00 (2006.01) A61K 47/02 (2006.01) A61P 13/02 (2006.01)

Patent

CA 2496780

A crystal for oral solid medicament comprised of indoline compound (KMD-3213) which exerts al-adrenaline receptor blocking effect, is useful as a therapeutic agent for dysuria and is represented by the formula: (I) wherein in the powder X-ray diffraction pattern, the compound is characterized by main peaks of 5.5° ~ 0.2°, 6.1° ~ 0. 2°, 9.8° ~ 0. 2°, 11.1° ~ 0.2°, 12.2° ~ 0. 2°, 16.4° ~ 0.2°, 19.7° ~ 0.2° and 20.0° ~ 0.2° as 2.theta. . There is further provided an oral solid medicament for dysuria treatment containing the crystal as an active ingredient. (see formula I)

Un cristal pour médicament solide à administration orale comprend un composé d'indoline (KMD-3213) qui exerce une activité de protection du récepteur de .alpha.¿1?-adrénaline, est utile en tant qu'agent thérapeutique pour la dysurie et est représenté par la formule (I), dans laquelle le composé, qui présente un motif de diffraction de rayons X en poudre, est caractérisé par les crêtes principales de 5,55·.plusmn. 0,2·, 6,1·.plusmn. 0,2·, 9,8·.plusmn. 0,2·, 11,1·.plusmn. 0,2·, 12,2·.plusmn. 0,2·, 16,4·.plusmn. 0,2·, 19,7·.plusmn. 0,2· et 20,0·.plusmn. 0,2· comme 2?. L'invention concerne aussi un médicament solide à administration orale destiné au traitement de la dysurie contenant le cristal en tant que principe actif.

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