Crystal form of quinoline compound and process for its...

Details Crystal form of quinoline compound and process for its... Crystal form of quinoline compound and process for its...

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2551050

A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1): The water content is adjusted to a level of from 5 to 15%, and the crystal form is controlled to be crystal form A, thereby to obtain a drug substance excellent in stability.

L'invention concerne une méthode de production d'une substance pharmaceutique de calcium de pitavastatine cristallin présentant une excellente stabilité. Lors de la production d'un composé (calcium de pitavastatine) de formule (1): la teneur en eau est réglée à un niveau compris entre 5 et 15 %; et la forme cristalline est régulée pour donner la forme cristalline A, ce qui permet de produire une substance pharmaceutique présentant une excellente stabilité.

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