Crystal forms and mutants of rank ligand

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/52 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) B01D 9/00 (2006.01) C07K 1/00 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C30B 29/58 (2006.01) G01N 33/566 (2006.01) G06F 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2456708

The present invention provides crystals of RANKL ectodomain complexes, detailed three dimensional structural information illustrating the interaction between RANKL and RANK and methods of utilizing the X-ray crystallographic data from such crystals and other structural data disclosed to design, identify and screen for compounds that modulate activity. The present invention also relates to machine readable media embedded with the three- dimensional atomic structure coordinates of RANKL crystalline complexes and subsets thereof, together with other structural data disclosed herein.

La présente invention concerne des cristaux de complexes d'ectodomaine RANKL, des informations détaillées portant sur la structure tridimensionnelle illustrant l'interaction entre RANKL et RANK, ainsi que des procédés d'utilisation de données de cristallographie par rayons X provenant de ces cristaux et d'autres données de structure présentées pour produire, identifier et cribler des composés qui modulent l'activité. Cette invention porte également sur un support lisible par une machine, intégré dans les coordonnées de structure atomique tridimensionnelle de complexes cristallins RANKL et de sous-ensembles de ces derniers, ainsi que d'autres données de structure présentées dans cette invention.

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