Crystal forms of...

Details Crystal forms of... Crystal forms of...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2554772

Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3- yloxy)~phenylamino]-quinazolin-6-yl}-allyl)-acetamide. A crystal form is useful in the synthesis of salts and complexes of E-2-Methoxy-N-(3-{4-[3- methyl-4-(6-methyl-pyridin-3-yloxy)~phenylamino]-quinazolin-6-yl}-allyl)- acetamide. A crystal form also improves stability of tabletted or capsuled E-2- Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)~phenylamino]-quinazolin- 6-yl}-allyl)-acetamide as a drug product.

La présente invention concerne des formes cristallines de E-2-Méthoxy-N-(3-{4-[3-méthyl-4-(6-méthyl-pyridine-3-yloxy)-phénylamino]-quinazoline-6-yl}-allyl)-acétamide. Une forme cristalline convient dans la synthèse de sels et de complexes de E-2-Méthoxy-N-(3-{4-[3-méthyl-4-(6-méthyl-pyridine-3-yloxy)-phénylamino]-quinazoline-6-yl}-allyl)-acétamide. une forme cristalline améliore aussi la stabilité de E-2-Méthoxy-N-(3-{4-[3-méthyl-4-(6-méthyl-pyridine-3-yloxy)-phénylamino]-quinazoline-6-yl}-allyl)-acétamide en cachet ou en gélule utilisé comme médicament.

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