C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/47 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2432137
The invention relates to crystal forms of 6-[4-chloro-phenyl)-hydroxy-(3- methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2- one, 2,3-dihydroxy butanedioate salts having formula shown below: (I) and to pharmaceutical compositions containing the above compound, methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above compouds, and to methods of preparing the crystal forms of the above compound and related compounds.
L'invention concerne des formes cristallines de sels de 6-[(4-chloro-phényl)hydroxy-(3-méthyl-3H-imidazol-4-yl)-méthyl]-4-(3-éthynyl-phényl)-1-méthyl-1H-quinoléine-2-one, 2,3-dihydroxybutanedioate représentées par la formule (I), ainsi que des compositions pharmaceutiques contenant ce composé, des procédés de traitement de maladies hyperprolifératives, telles que les cancers, chez des mammifères, particulièrement, les humains, par administration dudit composé et des procédés de préparation des formes cristallines dudit composé et de composés apparentés.
Li Zheng Jane
Lyssikatos Joseph Peter
Meltz Clifford Nathaniel
Newton Linda Sue
Tickner Derek Lawrence
Osi Pharmaceuticals Inc.
Pfizer Inc.
Pfizer Products Inc.
Smart & Biggar
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