C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/194 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07C 59/255 (2006.01)
Patent
CA 2632091
The invention relates to crystal forms of 6-[4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl- phenyl)-1-methyl-1H-quinolin-2-one, 2,3- dihydroxy butanedioate salts having formula shown below: (I) and to pharmaceutical compositions containing the above compound, methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above compouds, and to methods of preparing the crystal forms of the above compound and related compounds.
L'invention porte sur des formes cristallines des sels du 6-¬4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl|-4-(3-ethynyl-phenyl)-1-meth yl-1H-quinolin-2-one, 2,3-dihydroxy butanedioate ayant la formule présentée ci-dessous : I) et sur des préparations pharmaceutiques contenant le composé ci-dessus, des méthodes permettant de traiter des maladies dans lesquelles la prolifération est excessive, comme le cancer, chez les mammifères, en particulier les humains, par l'administration des composés ci-dessus, ainsi que sur des méthodes de préparation des formes cristallines du composé ci-dessus et des composés apparentés.
Li Zheng Jane
Lyssikatos Joseph Peter
Meltz Clifford Nathaniel
Newton Linda Sue
Tickner Derek Lawrence
Osi Pharmaceuticals Inc.
Pfizer Inc.
Pfizer Products Inc.
Smart & Biggar
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