C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61P 5/06 (2006.01)
Patent
CA 2572325
Crystalline polymorphs of (3 R)-1-(2-methylalanyl-D-tryptophyl)-3~ (phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
L~invention concerne des polymorphes cristallins d~acide (3 R)-1-(2-methylalanyl-D-tryptophyl)-3 (phenylmethyl)-3-piperidinecarboxylique 1,2,2-trimethylhydrazide utilisables comme agents pharmaceutiques. L~invention concerne également les procédés de production et d~isolation de ces polymorphes et les compositions pharmaceutiques que contiennent ces polymorphes ainsi que les procédés pharmaceutiques de traitement. Les polymorphes cristallins de cette invention servent à agir directement sur les cellules de l~hypophyse pour diffuser des hormones de croissance.
Littler Benjamin
Lorimer Keith
Paul Bernhard
Pines Seemon H.
Borden Ladner Gervais Llp
Helsinn Therapeutics (u.s.) Inc.
Sapphire Therapeutics Inc.
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