Crystal forms of olanzapine and processes for their preparation

Details Crystal forms of olanzapine and processes for their preparation Crystal forms of olanzapine and processes for their preparation

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2493370

The invention relates to a process for the preparation of form I of olanzapine, crystallized from a solvent mixture which comprises 2-propanol, some pseudopolymorphic forms, namely solvates of olanzapine, a new polymorphic form A of olanzapine, and processes for the preparation thereof.

L'invention concerne un procédé de préparation de la forme I de l'olanzapine, cristallisée à partir d'un mélange solvant contenant du 2-propanol, certaines formes pseudopolymorphiques, à savoir des solvates de l'olanzapine, une nouvelle forme polymorphique A de l'olanzapine ainsi que des procédés de préparation de ces dernières.

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