C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A01N 43/90 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2351712
The present invention relates to a defined crystal modification of 8-cyano- 1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro- 4-oxo-3-quinolinecarboxylic acid of the formula (I), to processes for its preparation and to its use in pharmaceutical preparations. (see formula I) The crystal modification can be distinguished from other crystal modifications of 8-cyano-1-cyclopropyl-7-(1S, 6S-2, 8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro- 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (I) by its characteristic X-ray powder diffractogram and its differential thermodiagram (see description).
L'invention concerne une modification cristalline définie d'acide 8-Cyan-1- cyclopropyl -7-(1S,6S-2, 8-diazabicyclo [4.3.0]nonan -8-yl)-6- fluor-1,4- dihydro-4- oxo-3-chinolincarboxylique de la formule (I), son procédé de production et son utilisation dans des préparations pharmaceutiques. Cette modification cristalline se distingue d'autres modifications cristallines de l'acide 8-Cyan-1- cyclopropyl -7-(1S,6S-2, 8-diazabicyclo [4.3.0]nonan -8-yl)-6- fluor-1,4- dihydro-4-oxo -3-chinolincarboxylique de la formule (I) par son diagramme de mesure par diffraction des rayons X caractéristique et son diagramme thermique différentiel (voir description).
Hallenbach Werner
Himmler Thomas
Rast Hubert
Aktiengesellschaft Bayer
Bayer Animal Health Gmbh
Fetherstonhaugh & Co.
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