C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01)
Patent
CA 2608078
Two crystal forms of (R)-3-[2-(2-amino-5-trifluoromethoxybenzamido)acetamido]- 1-(6-methylindol-3-ylmethyl)pyrrolidine which exhibit specific X-ray powder diffraction patterns or infrared absorption spectra, amorphous form thereof, a pharmaceutical composition containing the crystal or amorphous form as an active ingredient, as well as methods for preparing them are provided.
La présente invention concerne deux formes cristallines de la (R)-3-[2-(2-amino-5-trifluorométhoxybenzamido)acétamido]-1-(6-méthylindol-3-ylméthyl)pyrrolidine qui présentent des motifs de diffraction de poudre par rayons X ou des spectres d'absorption en infrarouge spécifiques, ainsi que la forme amorphe dudit composé, une préparation pharmaceutique contenant une forme amorphe ou cristalline au titre de principe actif, et des méthodes de synthèse de ces formes.
Ishikawa Yuji
Kawana Asahi
Sato Yoshinori
Suda Kaoru
Takahashi Yuji
Borden Ladner Gervais Llp
Teijin Pharma Limited
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