Crystal of hydroxynorephedrin derivative hydrochloride 1/4...

Details Crystal of hydroxynorephedrin derivative hydrochloride 1/4... Crystal of hydroxynorephedrin derivative hydrochloride 1/4...

C - Chemistry, Metallurgy

07

C

C07C 217/54 (2006.01) A61K 31/215 (2006.01) A61P 13/02 (2006.01)

Patent

CA 2605298

There is provided ethyl (-)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1- methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate hydrochloride 1/4 hydrate or its crystal, which can be identified by characteristic diffraction peaks of powder X-ray diffractometry, differential scanning calorimetry, etc., obtained by producing, through specified process, ethyl 2-[4-[2-[[1S,2R]-2-hydroxy-2-(4- hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate.

L'invention concerne du chlorhydrate d'éthyl(-)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphényl)-1-méthyléthyl]amino]éthyl]-2,5-diméthylphénoxyacétate 1/4 hydraté ou son cristal, qui peut être identifié par ses pics caractéristiques de diffraction en diffractométrie de rayons X sur poudre, de calorimétrie à balayage différentiel, etc., obtenu par fabrication, selon un procédé spécifique, d'éthyl 2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphényl)-1-méthyléthyl]amino]éthyl]-2,5-diméthylphénoxyacétate.

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