C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) A61K 31/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2522472
The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. The present invention additionally relates to crystals of PDE5 into which ligands may be soaked and crystals of PDE5 10 comprising PDE5 ligands that have been soaked into the crystal.
La présente invention concerne les cristaux absorbables d'une phosphodiestérase 5 (PDE5) et leurs utilisations pour identifier des ligands de PDE5, y compris des composés inhibiteurs de PDE5. La présente invention concerne également des méthodes pour identifier ces composés inhibiteurs, ainsi que leur usage médical. Elle concerne d'autre part des cristaux PDE5 dans lesquels des ligands peuvent être absorbés, et des cristaux de PDE5 renfermant des ligands de PDE5 ayant été absorbés dans le cristal.
Brown David Graham
Groom Colin Roger
Hopkins Andrew Lee
Jenkins Timothy Mark
Kamp Sarah Helen
Pfizer Inc.
Sim & Mcburney
LandOfFree
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