Crystal polymorph of hydroxynorephedrin derivative...

Details Crystal polymorph of hydroxynorephedrin derivative... Crystal polymorph of hydroxynorephedrin derivative...

C - Chemistry, Metallurgy

07

C

C07C 217/54 (2006.01) A61K 31/216 (2006.01) A61P 13/02 (2006.01)

Patent

CA 2605337

There is provided a novel crystal polymorph of ethyl (-)-2-[4-[2-[[1S,2R]-2- hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5- dimethylphenoxyacetate hydrochloride which can be identified by characteristic diffraction peaks of powder X-ray diffractometry, etc., through specified process from ethyl (-)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphenyl)-1- methylethyl]amino]ethyl]-2,5-dimethylphenoxyacetate hydrochloride.

L'invention concerne un nouveau cristal polymorphe De chlorhydrate d'éthyl(-)-2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphényl)-1-méthyléthyl]amino]éthyl]-2,5-diméthylphénoxyacétate, pouvant être identifié par ses pics caractéristiques de diffraction en diffractométrie de rayons X sur poudre, etc., obtenu par fabrication, selon un procédé spécifique, à partir de chlorhydrate d'éthyl -2-[4-[2-[[1S,2R]-2-hydroxy-2-(4-hydroxyphényl)-1-méthyléthyl]amino]éthyl]-2,5-diméthylphénoxyacétate.

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