Crystal structure of chorismate synthase and uses thereof

Details Crystal structure of chorismate synthase and uses thereof Crystal structure of chorismate synthase and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) C12N 9/10 (2006.01) C12Q 1/34 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2500140

The invention describes the identification of the structure coordinates for the enzyme Chorismate Synthase. There is a computer programmed to produce a three-dimensional representation of a molecule or molecular complex, wherein the molecule or molecular complex comprises a binding domain defined by the structure coordinates of (a) Arg 39, His 110, Ser 132, Thr 136, Lys 254, Gly 297, Lys 311, Thr 315, Arg 337 and Asp 339 ; or (b) Ser 9, His 10, Arg 39, Asp 54, Arg 107, His 110, Ser 132, Ala 133, Arg 134, Thr 136, Arg 337 and Asp 339. 1, or where the molecular complex or binding domain has a root mean square deviation of conserved residue backbone atoms of less than 2A when superimposed on the relevant backbone atoms described by the structure coordinates of said amino acids.

L'invention concerne l'identification des coordonnées de structure pour l'enzyme Chorismate Synthase. Un ordinateur est programmé pour produire une représentation tridimensionnelle d'une molécule ou d'un complexe moléculaire. Ladite molécule ou le complexe moléculaire comprend un domaine de liaison défini par les coordonnées de structure de (a) Arg 39, His 110, Ser 132, Thr 136, Lys 254, Gly 297, Lys 311, Thr 315, Arg 337 et Asp 339 d'après la figure (1); ou (b) Ser 9, His 10, Arg 39, Asp 54, Arg 107, His 110, Ser 132, Ala 133, Arg 134, Thr 136, Arg 337 et Asp 339 d'après la figure (1). Le complexe moléculaire ou le domaine de liaison peuvent présenter un écart type d'atomes de squelette résiduels conservés, inférieur à 2.ANG., lorsqu'ils sont superposés sur les atomes de squelette correspondant décrits par les coordonnées de structure desdits aminoacides.

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