C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/20 (2006.01) C12Q 1/34 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2362612
The present invention provides for crystalline cPLA2. The crystal structure of cPLA2 has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of cPLA2 activity and membrane binding using such models are also disclosed.
L'invention concerne la cPLA2 cristalline. La structure cristalline de cPLA2 a également été résolue à l'aide de cette matière. L'invention concerne également des modèles basés sur cette structure cristalline. L'invention concerne des méthodes permettant d'identifier des inhibiteurs de l'activité et de la fixation à la membrane de cPLA2 à l'aide de ces modèles.
Dessen Andrea
Seehra Jasbir S.
Somers William S.
Stahl Mark L.
Genetics Institute Inc.
Genetics Institute Llc.
Torys Llp
LandOfFree
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