Crystal structure of cpla2, and methods of identifying...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/20 (2006.01) C12Q 1/34 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2362612

The present invention provides for crystalline cPLA2. The crystal structure of cPLA2 has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of cPLA2 activity and membrane binding using such models are also disclosed.

L'invention concerne la cPLA2 cristalline. La structure cristalline de cPLA2 a également été résolue à l'aide de cette matière. L'invention concerne également des modèles basés sur cette structure cristalline. L'invention concerne des méthodes permettant d'identifier des inhibiteurs de l'activité et de la fixation à la membrane de cPLA2 à l'aide de ces modèles.

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