C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C30B 7/00 (2006.01) G01N 23/20 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2654438
The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.
La présente invention concerne la détermination de la structure cristalline du récepteur spécifique des macrophages, CRIg (auparavant appelé STIgMA), et de son complexe avec les sous-unités C3b et C3c du complément C3 (complexes C3b:CRIg et C3c:CRIg). L'invention concerne également l'utilisation de la structure cristalline de CRIg ou du complexe C3b:CRIg pour le criblage et l'identification de molécules structuralement et/ou fonctionnellement associées à CRIg, telles que des agonistes et des antagonistes de CRIg.
Hass Phillip
Katschke Kenneth Jr.
Steffek Micah
Van Lookeren Campagne Menno
Wiesmann Christian
Genentech Inc.
Smart & Biggar
LandOfFree
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