Crystal structure of dipeptidyl peptidase iv (dpp-iv) and...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/64 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C40B 30/02 (2006.01) G06F 19/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2569095

A crystal structure of dipeptidyl peptidase IV (DPP-IV), and the three- dimensional atomic coordinates of the DPP-IV extracellular domain, as described and used for the identification of ligands, including DPP-IV inhibitors, used for the treatment of diseases that are associated with proteins that are subject to processing by DPP-IV.

Selon l'invention, une structure cristalline de dipeptidyl peptidase IV (DPP-IV) et les trois coordonnées atomiques tridimensionnelles du domaine extracellulaire de DPP-IV, telles que décrites et utilisées pour l'identification de ligands, dont les inhibiteurs de DPP-IV, sont utilisées pour traiter des maladies associées à des protéines soumises à un traitement par DPP-IV.

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