Crystal structure of escherichia coli gdp-fucose synthetase...

Details Crystal structure of escherichia coli gdp-fucose synthetase... Crystal structure of escherichia coli gdp-fucose synthetase...

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01) C12N 9/04 (2006.01) C12N 9/90 (2006.01)

Patent

CA 2340074

The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.

La présente invention concerne la GFS (GDP-fucose synthétase) cristalline. La structure cristalline de GFS a également été établie à l'aide de cette matière. L'invention concerne également des modèles basés sur cette structure cristalline. L'invention concerne en outre des procédés d'identification d'inhibiteurs de l'activité de GFS à l'aide de ces modèles.

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