Crystal structure of pim-1 kinase

Details Crystal structure of pim-1 kinase Crystal structure of pim-1 kinase

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/47 (2006.01) A61K 31/519 (2006.01) C07D 215/00 (2006.01) C07D 235/30 (2006.01) C07D 471/04 (2006.01) C30B 29/58 (2006.01) G01N 23/20 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2503905

A crystal structure of PIM-1 is described that was determined by X-ray crystallography. The use of PIM-1 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PIM- 1 and other PIM kinases.

L'invention concerne une structure cristalline de PIM-1 détectée par cristallographie aux rayons X. Les cristaux de PIM-1 et les informations structurales obtenues peuvent être utilisées, par exemple, pour identifier des échafaudages moléculaires et développer des ligands qui se fixent sur les protéines kinases PIM-1 et d'autres protéines kinases PIM et les modulent.

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