Crystal structure of ribosomal protein l11/gtpase activating...

Details Crystal structure of ribosomal protein l11/gtpase activating... Crystal structure of ribosomal protein l11/gtpase activating...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2371245

The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The meth- ods are useful in identifying compounds useful for anti-bacterial treatments.

L'invention concerne généralement des méthodes de dépistage de composés de modulation d'ARN de la région (GAR) activant la GTPase de la protéine ribosomique L11, en utilisant des informations de la structure à haute résolution du complexe L11/GAR. Ces méthodes sont utiles à l'identification de composés utilisés dans des traitements antibactériens.

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