Crystal structure of the 30s ribosome and its use

Details Crystal structure of the 30s ribosome and its use Crystal structure of the 30s ribosome and its use

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 47/42 (2006.01) C07K 14/195 (2006.01) C12Q 1/18 (2006.01) G01N 33/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2352399

The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of a = 401.4 ~ 4Ø.ANG., b = 401.4 ~ 4ØANG., c = 175.9 ~ 5ØANG.. An advantageous feature of the structure is that it diffracts beyond 3.ANG. resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in Tables 1A and 1B. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.

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