Crystal structure of the (aml1 runt domain) / (cbfbeta)...

Details Crystal structure of the (aml1 runt domain) / (cbfbeta)... Crystal structure of the (aml1 runt domain) / (cbfbeta)...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2399875

The present invention relates to a crystal comprising the AML1 Runt domain and/or CBF.beta.. The invention also relates to a structural model of the AML1 Runt domain and/or CBF.beta., and of the interaction of the AML1 Runt domain with DNA, and an improved means for the design of ligands which are capable of binding the AML1 Runt domain and/or CBF.beta. and/or modulating the DNA- binding capacity of the AML1 Runt domain.

Cette invention a trait à un cristal comprenant le domaine AML1 Runt et/ou CBFb. Elle porte également sur un modèle structurel du domaine AML1 Runt et/ou CBFb ainsi que sur un modèle de l'interaction du domaine AML1 Runt avec l'ADN. Elle porte, en outre, sur des améliorations apportées à la mise au point de ligands capables de fixation au domaine AML1 Runt et/ou CBFb et/ou de modulation de la capacité de fixation à l'ADN du domaine AML1 Runt.

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