Crystal structures of a protein tyrosine kinase

Details Crystal structures of a protein tyrosine kinase Crystal structures of a protein tyrosine kinase

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2263838

The present invention relates to the three-dimensional structures of a protein tyrosine kinase optionally complexed with one or more compounds. The atomic coordinates that define the structures of the protein tyrosine kinase and any of the compounds bound to it are pertinent to methods for determining the three-dimensional structures of protein tyrosine kinases with unknown structure and to methods that identify modulators of protein tyrosine kinase functions.

La présente invention concerne les structures tridimensionnelles d'une protéine tyrosine kinase formant éventuellement un complexe avec un ou plusieurs composés. Les coordonnées atomiques qui définissent les structures de la protéine tyrosine kinase et de tout composé qui lui est attaché sont appropriées à des procédés destinés à déterminer les structures tridimensionnelles de protéines tyrosine kinases à structure inconnue et à des procédés permettant d'identifier des modulateurs de fonctions de protéines tyrosine kinases.

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