C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/10 (2006.01)
Patent
CA 2431901
The present invention relates to a crystal comprising the ligand binding pocket of a glycosyltransferase enzyme and optionally a donor molecule or analogue thereof and/or an acceptor molecule or analogue thereof. The present invention also relates to the use of such a crystal to identify ligands capable of modulating glycosyltransferase activity, and the use of such ligands in therapeutic applications.
La présente invention concerne un cristal comprenant la poche de liaison de ligand d'une enzyme glycosyltransférase et éventuellement une molécule donneur ou un analogue de cette dernière et/ou une molécule accepteur ou un analogue de cette dernière. Cette invention concerne également l'utilisation d'un tel cristal pour identifier des ligands capables de moduler l'activité glycosyltransférase et l'utilisation de ces ligands dans des applications thérapeutiques.
Dieckelmann Manuela
Ly Hoa
Persson Karina
Strynadka Natalie C.j.
Wakarchuk Warren
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of British Columbia
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