C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.4
C07K 14/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1246549
- 1 - Abstract of the disclosure: The invention relates to a process for the pre- paration of crystal suspensions of one or more insulin derivatives of the formula I Image (I) R1 denotes H or H-Phe, R30 represents the radical of a neutral L-aminoacid which can be genetically coded and R31 represents a physiologically acceptable organic group of basic character with up to 50 carbon atoms, in the build-up of which 0 to 3 .alpha.-aminoacids parti- cipate and in which any terminal carboxyl function present can be free, as the ester function, as the amide function, as the lactone or reduced to CH2OH, with an isoelectric point between 5.8 and 8.5, which comprises carrying out the crystallization in an aqueous medium close to the isoelectric point of the derivative or derivatives in the presence of an aromatic hydroxy compound, to crystals and crystal suspensions obtainable by the process and to the use thereof.
459844
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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