C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) A61K 31/59 (2006.01)
Patent
CA 2359084
A method of purifying 1.alpha.-hydroxyvitamin D2 to obtain 1.alpha.- hydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent selected from the group consisting of ethyl formate, ethyl acetate and a 2-propanol-hexane mixture under inert atmosphere, dissolving a product containing 1.alpha.-hydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1.alpha.-hydroxyvitamin D2 crystals, and recovering the 1.alpha.-hydroxyvitamin D2 crystals. Optionally, petroleum ether may be added to the solvent after dissolving the product to be purified in the solvent.
Procédé de purification de 1.alpha.-hydroxyvitamine D¿2?, qui permet d'obtenir de la 1.alpha.-hydroxyvitamine D¿2? sous forme cristalline. Ledit procédé consiste à porter à ébullition un solvant choisi dans le groupe constitué par formate d'éthyle, acétate d'éthyle et un mélange de 2-propanol-hexane dans une atmosphère inerte, à dissoudre un produit contenant de la 1.alpha.-hydroxyvitamine D¿2? à purifier dans le solvant, à refroidir le solvant et le produit dissous à une température inférieure à la température ambiante pendant un laps de temps suffisant pour permettre la formation d'un précipité de cristaux de1.alpha.-hydroxyvitamine D¿2?, et à récupérer les cristaux de 1.alpha.-hydroxyvitamine D¿2?. Eventuellement, il est possible d'ajouter de l'éther de pétrole au solvant après dissolution du produit dans le solvant.
Deluca Hector F.
Holden Hazel
Sicinski Rafal R.
Thoden James Brian
Borden Ladner Gervais Llp
Wisconsin Alumni Research Foundation
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