C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/34 (2006.01) A61K 31/40 (2006.01)
Patent
CA 2220018
Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.- dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1- heptanoic acid hemi calcium salt designated Form I, Form II, and Form IV are characterized by their X-ray powder diffraction and/or solid state NMR are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia and hypercholesterolemia.
Formes cristallines nouvelles d'hémi-sel de calcium d'acide [R-(R*,R*)]-2-(4-fluorophényl)-.beta.,.delta.-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque, désignées sous les noms de Forme I, Forme II et Forme IV, caractérisées par leur diffraction des rayons X sous forme pulvérulente et/ou leur résonance magnétique nucléaire à l'état solide. Sont également décrits leurs procédés de préparation et la compositions pharmaceutique correspondante, ces composés étant utiles comme agents de traitement de l'hyperlipidémie et de l'hypercholestérolémie
Briggs Christopher A.
Harasawa Kikuko
Ichikawa Shigeru
Jennings Rex Allen
Minohara Kazuo
Torys Llp
Warner-Lambert Company
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