C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/4706 (2006.01) C07D 215/54 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2569007
The invention relates to the crystalline and amorphous forms of the desmotrop of general formula (IB) and its salts and solvates. - where in the formula R represents benzyl-, 2-(thienyl)methyl- or 2-(furyl)methyl group and R1 represents phenyl or furyl group substituted with C1-4 alkoxy group or halogen atom, to pharmaceutical compositions containing as for active ingredient the desmotrop of general formula (IB), and to preparation of the crystalline and amorphous forms of desmotrops (IA) and (IB).
L'invention concerne des formes cristallines et amorphes de desmotropes représentés par la formule générale (IB), ainsi que ses sels et solvates, dans laquelle R représente benzyl-, 2-(thiényl)méthyl- ou un groupe 2-(furyl)méthyl et R1 représente un groupe phényle ou furyle substitué par un groupe alcoxy C1-4 ou un atome halogène. L'invention concerne également des compositions pharmaceutiques qui contiennent comme principe actif le desmotrope de formule générale (IB), ainsi que la préparation des formes cristallines et amorphes des desmotropes (IA) et (IB).
Finta Zoltan
Heja Gergely
Hermecz Istvan
Horvath Agnes
Kiss Gyulane
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis
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